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Just Released - Transplantation Direct - February Issue

The February 2025 issue of Transplantation Direct is out and ready for viewing. In the basic sciences, we feature an article on immune cell subsets, especially those involved in alloantibody responses, that are suppressed by CXCR5+CD8+ T cells. In clinical kidney transplantation, this issue contains investigations on DSA levels and long-term outcomes after Imlifidase treatment, device-related healthcare-associated infections even under intense prevention protocols, assessment of aortoiliac CT angiography for surgical prep, and the use of Alport Syndrome organ donors. On the topic of liver transplantation, there are studies on the use of sorafenib in transplant recipients with HCC, risk factors related to expedited liver transplant evaluations, and pre/post-transplant travel patterns after implementation of acuity-circle policies in the US. On other topics, investigators report on a quality of life assessment in double-lung transplant recipients that experience baseline lung dysfunction; in hematopoietic stem cell transplantation, there is a study on the impact of G-CSF treatments on engraftment. We welcome everyone to visit our open access Transplantation Direct website for all the details on these, and other, articles.

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WTC 2025 Abstract Submission - 12 Days left!

Don’t miss out on this chance to be part of the world’s premier transplant event!

You have until February 19, 2025, to submit your research and contribute to the global dialogue on the latest advancements in the field of transplantation.

Visit the Abstract Submission Page for more details and submit your abstract by clicking the button below.
Click for Details
Submission Deadline:
February 19, 2025.

In Memory of Professor Frans Claas: A Visionary in Transplantation

The transplantation community is deeply saddened by the sudden passing of Professor Frans Claas on 2 February, while on holiday in South Africa. Professor Frans Claas was a pioneering scientist and esteemed mentor who dedicated his career to advancing transplant immunology at Leiden University Medical Center, The Netherlands. His groundbreaking work in HLA matching aiming to improve outcomes for transplant patients, transformed organ allocation and immunological risk assessment, playing a vital role in improving transplant success rates and patient outcomes.
Words cannot fully express how grateful the editors of the Transplantation Journal are for his invaluable contributions. He wrote and reviewed countless manuscripts, providing insightful feedback that helped authors refine and strengthen their studies. In a memorable interview, Frans shared his motivations, reflected on the pivotal role of Eurotransplant in his career, and discussed the future opportunities in transplantation.
Click to read his 2020 interview in Transplanttion
More than a brilliant scientist, Frans was kind, collegial, and charismatic, always ready to support and inspire others. A dedicated sportsman, he once ran marathons and cherished time with his wife Ilse, children, and grandchildren.
His legacy will live on in the many lives he touched. He will be deeply missed. Our thoughts are with his family during this difficult time.
- Carla Baan, On behalf of the Editors of Transplantation and Transplantation Direct
Professor Frans H.J. Claas
Read the Eurotransplant Obituary

News Spotlight

NY Times - A 66-year-old man from New Hampshire became the fourth person to receive a pig’s kidney.

Tim Andrews of Concord, N.H., here with his doctor, Leonardo Riella, received a pig’s kidney in late January and was well enough to be discharged a week later.(Credit - Billy Hickey for The New York Times)
Feb 7 - Surgeons in Boston successfully transplanted the kidney of a genetically modified pig into a 66-year-old man with kidney failure last month, Massachusetts General Hospital announced on Friday.
NEW YORK TIMES ARTICLE
CNN ARTICLE

Feb 4 - The first clinical trial testing whether pig kidneys can be safely transplanted into living people has been approved by the US Food and Drug Administration (FDA)

As part of the trial, which will begin later this year, kidneys from genetically modified pigs will be transplanted into people with chronic kidney disease whose organs no longer function independently.

The FDA’s green light will bring the experimental procedure a step closer to one day supplying organs to the thousands of people who are waiting for a donor organ. “The start of formal clinical trials is very exciting,” says Jay Fishman, IXA President-Elect.

“The humans who have received xenotransplants have made a tremendous contribution to our field,” Fishman says. But formal clinical trials are standardized, and can therefore produce important information, including crucial safety and efficacy data, to move the field forwards, he says.

READ THE ARTICLE
IXA 2025 Congress - ixa2025.org
Sanjay Nagral (India), Co-Chair
Custodian Group Board of Councillors
Declaration of Istanbul

Should your doctor say “I don’t know"?
Dr. Sanjay Nagral | TEDx

Jan. 29 - Doctor Patient Communication and Approach to Holistic and Optimal healthcare is crucial part of Medicine. This talk challenges the conventional patient doctor relationship and gives a fresh perspective to shared decision making in personalized patient care. .
Watch on YouTube
Credit: Photo by Robina Weermeijer on Unsplash

TTS Members Atul Humar and Deepali Kumar receive CIHR Catalyst Grant funding

Jan. 28 - Congratulations to TTS Members Atul Humar and Deepali Kumar for receiving the Catalyst Grant funding for their work on 'Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)'

IPITA 2025 - Congress Website and Abstract Submission Now Open!

The program promises to be a truly exciting and thought-provoking experience, with cutting-edge topics such as chemical reprogramming for cell fate manipulation, advancements in pancreas transplantation, personalized immunoprofiling, and the potential of stem cell-derived insulin-producing cells. These discussions will push the boundaries of our understanding and offer new perspectives on the evolving field of diabetes care.

Submission Deadline: February 21, 2025

Upcoming Webinar Presentations

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CLICK HERE FOR DETAILS

Transplantation Journal Highlights

Transplantation Journal - Social Media Content

Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance
The Clinical Tolerance Workshop series was established by the late Dr Sam Strober and colleagues with the goal of bringing together investigators working in the field of transplantation tolerance. For the first time, the meeting was held outside the United States. The Sixth International Workshop was run from the March 25–26, 2024 at Exeter College, University of Oxford. International world-leading scientists and clinicians gave updates on their ongoing research into tolerance induction through cell therapies and chimerism, with the goal of immunosuppression (IS) withdrawal.
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BCL6 Alleviates Hepatic Ischemia/Reperfusion Injury Via Recruiting SIRT1 to Repress the NF-κB/NLRP3 Pathway
Hepatic ischemia/reperfusion (I/R) injury (HIRI) is an intrinsic phenomenon observed in the process of various liver surgeries. Unfortunately, there are currently few options available to prevent HIRI. Accordingly, we aim to explore the role and key downstream effects of B-cell lymphoma 6 (BCL6) in hepatic I/R (HIR).
Read More

Transplantation Direct - Social Media Content

Evaluating Quality and Readability of AI-generated Information on Living Kidney Donation
The availability of high-quality and easy-to-read informative material is crucial to providing accurate information to prospective kidney donors. The quality of this information has been associated with the likelihood of proceeding with a living donation. Artificial intelligence–based large language models (LLMs) have recently become common instruments for acquiring information online, including medical information. The aim of this study was to assess the quality and readability of artificial intelligence-generated information on kidney donation.
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Mitigating High-risk EBV and CMV Through Kidney Paired Donation: A Survey of Potential Donor and Recipient Candidates
High-risk cytomegalovirus (CMV) and Epstein-Barr virus (EBV) mismatches (ie, seropositive donors to seronegative recipients) among kidney transplant recipients lead to increased healthcare utilization, inferior allograft outcomes, and high mortality. We assessed the interest among prospective kidney donor and recipient candidates to participate in kidney paired donation (KPD) for averting CMV/EBV high-risk mismatches.
READ MORE

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Membership Renewals

Membership renewal notices for TTS and Section Members were sent out December 6th. If you are a member please log into your account to pay your dues and update your profile.
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In the News

Upcoming Meetings and Announcements 

ISUTx 2025

October 2-3, 2025 | Antalya, Turkey
5th State-of-the-Art Meeting of the International Society of Uterus Transplantation

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