Founder, National Transplant Organization Madrid
Institut d'investigacions Biomèdiques August Pi i Sunyer
Professor of Transplantation, University of Oxford
This month brings the largest issue of Transplantation Direct we have published to date. Several articles concentrate on early factors affecting kidney transplant outcomes including EBV load/PTLD, cold-ischemia times in circulatory death and small pediatric donors, inflammation in extended criteria donors, and ABO/HLA incompatibility. Sirolimus effects on T cells in UV-exposed skin and the relationship of specific microRNAs to acute rejection are also explored in renal transplantation. In liver transplantation, factors influencing outcomes are studied including fever/pancytopenia, donor diabetes/cold ischemia times, body mass index and donor age/graft volume in elderly living donor recipients. A prospective randomized multicenter trial on liver perfusion method is reported, as well as outcomes in liver transplant recipients with autoimmune disease not receiving steroids. We also publish a report on a pancreas transplant surgery repair method, and on a method of hepatocyte cell preservation for cell transplantation. In heart transplantation, the issue of frailty after bridge-to-transplant is investigated. Finally, a preconditioning tolerance protocol in porcine lung transplantation involving splenocyte infusion is also described herein. We are pleased with the steady progress of Transplantation Direct and hope that it is serving you well.
Submitted by Dr Joel Adler, Editorial Fellow, Transplantation.What Is the Future of Generics in Transplantation?
Given the long-term need for immunosuppressive medication, use of lower-cost generic therapeutics is of interest to transplant recipients. Regulatory procedures, market penetration, and the use of generic immunosuppressive drugs vary across countries. Van Gelder examines the current state of generic antihypertensives, including clinical trials, registration protocols, patient adherence, and cost. Given the narrow therapeutic window of these medications, all of these factors must be taken into careful consideration.
Researchers develop microneedle patch for flu vaccination
June 27 - A team at the Georgia Institute of Technology and Emory University has shown that an influenza vaccine can produce robust immune responses and be administered safely with an experimental patch of dissolving microneedles. The method is an alternative to needle-and-syringe immunization; with further development, it could eliminate the discomfort of an injection as well as the inconvenience and expense of visiting a flu clinic.
TTS has created a Heart and Lung Committee at the beginning of 2017 (Chair: Peter MacDonald - Australia; Members: Tobias Deuse - United States, Shaf Keshavjee - Canada, Christian Benden - Switzerland, Peter Hopkins - Australia, Kumud Dhital - Australia)to provide relevance, opportunity and representation for heart and lung professionals worldwide. At an international level, there are ample opportunities within the group for: learning from each other, establishing clinical and research collaborations and creating additional networks for mentorship and training.
Sobnach S, Muller E.
Transplant Unit & Division of General Surgery, Groote Schuur Hospital / University of Cape Town, Anzio Road, Cape Town 7925
The South African transplant context in unique; the junior doctor is often the first point of contact between a potential donor and the organ procurement team. Over the past decade, we studied the perspectives of our medical students regarding organ transplantation, with a view to integrating a formal training program in the current undergraduate medical curriculum. Only 8% of our medical students are registered organ donors, and only 18% know how to access transplant resources for their future patients. Although the great majority (95%) are willing to further their education regarding transplant issues, our surveys have concluded that consistently low levels of knowledge prevail amongst our medical student population. Only 6% were fully aware of the organ transplants performed in South Africa. Our greatest concern is that only half of our graduating medical students can confidently perform brain death testing and confirm its diagnosis. Our institution now offers transplantation lectures to medical students during their clerkships. We have also consistently emphasized to medical educators that Organ Transplantation in South Africa is not a subspecialized field, but rather a major public health challenge that needs to be addressed at the grass root
The Transplantation Society
505 Boulevard René-Lévesque Ouest
Montréal, QC, H2Z 1Y7