Date and time: January 19th, 2018 2:00 PM EST (UTC-5 hours)
Topic: Antibody Mediated Rejection in Liver Transplantation Part I - Role of DSA's and Treatment Options
Description: Antibody mediated rejection (AMR) has become one of the hot topics in liver transplantation recently. In this webinar, world known experts in this topic will discuss the immunological, clinical aspects of AMR as well as available treatment options.
|Organizer: Professor Sukru Emre, MD
Professor of Surgery (Transplant) and of Pediatrics, Yale University, USA
|Moderator: Udeme D Ekong, MD, MPH
Associate Professor of Pediatrics (Gastroenterology), Yale University, USA
|Discussant: Laura J. Wozniak, MD
Assistant Clinical Professor of Pediatrics in the Division of Gastroenterology, Hepatology, and Nutrition at UCLA, USA
|Discussant: Jacqueline O'Leary, MD, MPH
Medical Director of Research for the Baylor Simmons TransplantInstitute in Dallas, Texas, USA
|Speaker: Professor Sandy Feng, MD, PhD
Professor of Surgery in Residence Director, Abdominal Transplant Surgery Fellowship University of California San Francisco
Overview: The demand for kidney transplantation continues to rise inexorably as its life-saving and life-enhancing benefits are strongly established. The supply of kidneys remains sorely inadequate both in quantity and, very importantly, quality. These two factors combine to exert tremendous pressure to accomplish transplantation by aggressively utilizing all available deceased donor organs. This webinar will consider donor, recipient, transplant, and other relevant factors, as well as their potential interplay, that enter into the critical decision of whether to transplant or not to transplant.
January 8 - Professor Shinya Yamanaka of Kyoto University, 55, became more widely known after he was awarded the Nobel Prize in Physiology or Medicine in 2012. Five years before that, however, in November 2007, he announced that he had generated human-induced pluripotent stem cells (iPS cells).
The FDA granted Shire's Phase III-stage drug maribavir (SHP620) Breakthrough Therapy Designation for treating cytomegalovirus (CMV) infection and related disease in transplant patients who are resistant or refractory to previous therapy.
January 3 - LA Times - The disparities stem from a principle that has always guided the national transplant system: local first. Most organs stay in the areas where they are donated, even if sicker patients are waiting elsewhere.
January 10 - MedicalXpress - Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery from heart attack injury.
January 10 - Specialty Pharmacy Times - Study shows that transplanting HCV-positive livers into HCV-negative patients and treating with new antivirals can reduce waiting time to transplant and improve overall life expectancy
Jan. 9 - The Daily Star - Parliament today passed the Transplantation of Human Organs Bill, 2018 with a provision of 3 years of rigorous imprisonment or Tk 10 lakh fine or both for violation of the law in a bid to check the illegal trade of human organs.
Plasma Exosomes From HLA-Sensitized Kidney Transplant Recipients Contain mRNA Transcripts Which Predict Development of Antibody-Mediated Rejection
Zhang H1, Huang E, Kahwaji J, et al.
Exosomes are extracellular vesicles present in all types of biological fluid including blood; their molecular constituents have been shown to be potential biomarkers in disease. The measurement of mRNA transcripts from plasma exosomes in renal transplantation patients has not been previously described. In this study the authors evaluated the feasibility of quantifying mRNA expression of 21 preselected genes in plasma exosomes to predict antibody mediated rejection (AMR) in a renal transplant cohort. The study group (64 patients, 152 plasma samples) was divided into those who developed antibody-mediated or mixed rejection (AMR group), cell- mediated rejection (CMR group), and those with no rejection (desensitized (DES) and non-DES control groups). Samples collected within 1 month prior to the rejection episode were included. Significant increases in transcript expression of multiple genes was identified in the AMR group compared to other groups, as was a gene combination score calculated from 4 genes. This demonstrated the feasibility of quantifying mRNA transcript levels of various genes in plasma exosomes of renal transplant patients, and plasma exosomes as a potential source of biomarker discovery in rejection.
We want you to contribute to the Congress by finding a gap in the congress program and submitting your own proposal to fill it. Submissions will be reviewed by the Program Committee and the top proposals will be voted on by the community. Winners will be part of the official program and be hosted in the TTS Innovation Studio in the Exhibit Hall.
TTS is seeking nominations for three Officer positions that will be vacated in 2018: President-Elect, Vice President and Treasurer. In addition, five of the 12 Councilors-at-large will be changing.
The Medawar Prize, named after Society co-founder Sir Peter Medawar, is recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation.
The Transplantation Society bestows Honours and Awards to recognize individuals contributing to the field of transplantation through outstanding achievement (for basic scientists, clinicians and in developing countries), and mentorship and training. All members of TTS in good standing are eligible to make nominations and to be nominated for these Awards.
The Women in Transplantation (WIT) Steering Committee have created the Woman Leader in Transplantation Award to recognize a woman who has helped further the field of transplantation through research, policies, leadership, initiatives or other regarded contributions. Also created by the WIT Steering Committee, the Unsung Hero Award will be presented to one woman who has had an extraordinary impact in transplantation through community service, volunteering, mentorship or other community based activity.
The Transplantation Science Committee together with The Transplantation Society and Transplantation are pleased to announce the best manuscripts published by the journal in 2017. Named after two pioneering giants, a selection committee that included editors of Transplantation, The Transplantation Society, in addition to members and chairs of the Transplantation Science Committee will select two winners amongst a very competitive group of publications.