|Organizer/Moderator: Professor Sukru Emre, MD
Professor of Surgery (Transplant) and of Pediatrics, Yale University, USA
|Discussant: Carlos O. Esquivel, MD, PhD
Arnold and Barbara Silverman Professor in Pediatric Transplantation,
Stanford University School of Medicine, Stanford, CA, USA
|Discussant: Simon P. Horslen, MB ChB
Director of the Hepatobiliary and Intestinal Failure programs
Medical Director for Solid Organ Transplantation, Seattle Childrens Hospital, USA
Submitted by Dr Andrea Schlegel, Editorial Fellow, Transplantation.
Wiebe C, Kosmoliaptsis V, Pochinco D, Taylor C, Nickerson P..
Transplantation. doi: 10.1097/TP.0000000000002117.
The authors present the first comparison of available scoring systems to assess HLA donor-recipient mismatches and their correlation with the development of de novo donor-specific antibody (dnDSA) in kidney transplant recipients on active immunosuppression. The authors determined HLA-DR and DQ molecular mismatches at the molecular level comparing 3 different methods: an eplet analysis that identifies small patches of surface exposed mismatched amino acids, an amino acid mismatch scoring physicochemical properties of all mismatched amino acid sequence polymorphisms, and an electrostatic mismatch that assesses the HLA tertiary structure for unique electrostatic potential profiles. The authors tested those methods in 596 renal transplant recipients and correlated their results with the development of HLA-DR/DQ dnDSA´s. Authors demonstrate a good correlation among the 3 scoring systems (R2=0.85-0.96). Importantly, HLA-DR and DQ free survival after kidney transplantation equally correlated with Eplet, amino acid and electrostatic mismatches (p<0.0001). Notably, all 3 methods predicted the development of dnDSA in a multivariate analysis after adjustment for recipient age, immunosuppression, and nonadherence, thus providing precise methods of alloimmune risk assessment.
UPDATE OF THE INTERNATIONAL INTESTINAL TRANSPLANT REGISTRY AND INTESTINAL TRANSPLANT OUTCOMES
Speaker: Matthew Everly, PharmD, BCPS, FAST, Director, Terasaki Research Institute, Los Angeles, CA, USA
March 3 - The Sindh Institute of Urology and Transplantation (SIUT) on Friday opened its state-of-the-art Bashir Dawood Transplant Operating Theatre Complex equipped to carry out up to four transplant surgeries simultaneously.
March 6 - In a small study, doctors at Johns Hopkins have successfully transplanted 10 hepatitis C-infected kidneys into patients without hepatitis C and prevented the patients from becoming infected by hepatitis C. The success of these transplants could mean more organs being available for the nearly 100,000 people in the U.S. currently waiting for a kidney transplant.
February 28 - Scientists at the Diabetes Research Institute (DRI), University of Miami, have identified and characterized a population of progenitor cells located in defined areas of the human pancreas, which can be stimulated to develop into glucose-responsive beta cells.
February 28 - To improve patient outcomes, physicianresearchers in Cleveland Clinic’s Liver Cancer Program have developed a new transplantation protocol for treating liver metastases from CRC.
March 1 - Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body's ability to regenerate.
March 2 - Researchers from the Murdoch Children's Research Institute (MCRI), University of Melbourne and Leiden University Medical Centre (LUMC) in The Netherlands have made an important step towards making human kidneys from stem cells that they one day hope can be used to treat kidney disease.
March 3 - In a world-first, Melbourne's Austin Health has reapplied how the drug Terlipressin is given to patients waiting for a liver transplant, reducing the length of hospital stays and improving their post-surgery recovery.
March 6 - Surgeons and scientists at Baylor College of Medicine and the Texas Heart Institute will study the utility of previously unused organs to increase the number of heart transplantations, potentially making transplant possible for thousands of patients who die while waiting for an acceptable heart to become available.
March 8 - The company built a 3-D heart scanner that it hopes will change how ERs treat chest pain
Mar. 8, 2018 - The Japan News -The Yomiuri Shimbun A team of scientists says it has created a pig that can be used in transplantations in humans. According to the team, which includes researchers from Meiji University and Kyoto Prefectural University, the animal is the first to be developed for transplantation based on national guidelines ..
Researchers have learned a tremendous amount about how the human immunodeficiency virus (HIV), which causes AIDS, infects immune cells. Much of that information comes from studying immune cells in the bloodstream of HIV-positive people. Less detailed is the picture of how HIV interacts with immune cells inside the lymph nodes, where the virus can hide. In this image of lymph tissue taken from the neck of a person with uncontrolled HIV infection, you can see areas where HIV is replicating (red) amid a sea of immune cells (blue dots). Areas of greatest HIV replication are associated with a high density of a subtype of human CD4 T-cells (yellow circles) that have been found to be especially susceptible to HIV infection.