December 5 - A modified protocol has enabled baboons that received transplanted pig hearts to survive for more than six months. This improvement on previous efforts brings pig-to-human heart transplants a step closer.
December 5 - A Brazilian baby will celebrate her first birthday later this month, less than two years after her mother—unable to carry a pregnancy because she lacked a uterus—underwent a transplant from a deceased donor. The mother is the first in the world to give birth after such a transplant, a feat doctors were not sure would ever be possible.
December 5 - The new plan eliminates geographical boundaries drawn years ago that had largely given transplant centers first shot at livers collected from brain-dead donors in hospitals nearby. It moves the liver transplant system farther toward a “sickest-first” model that would send organs to recipients more than 500 miles away if they demonstrate the greatest need.
December 4 - A big challenge in unlocking the mysteries of aging is how long you need to study humans, or even human cells, to get answers. But, in partnership with NASA, NIH is hoping that space will help facilitate this important area of research
December 4 - (American Heart Association) Researchers say the ever-growing waiting list of hopeful heart transplant recipients could be trimmed down if only more patients were given the option to open their hearts to unlikely donors.
November 30 - Less than 11 months after Cameron Underwood underwent a face transplant, the 26-year-old is revealing himself to the world. Underwood, of Yuba City, California, sustained a self-inflicted gunshot to the face in June 2016. The extensive damage left him missing most of his lower jaw, his nose and every tooth but one, a statement said. He also experienced damage to his upper face and palate.
December 3 - Desperate Australians are being targeted by blackmarket organ dealers through social media as demand for kidneys and livers outstrips supply. With a significant shortage of organs available for transplantation in Australia, a parliamentary committee report is urging the government to act to prevent a boom in black market organs. There were 1,423 people listed on organ transplant waiting lists in Australia in September, 1003 of which were waiting on a new kidney transplants
November 29 - Clinicians of various specialties require autologous implantable tissues to repair and replace damaged tissue caused by diseases or trauma. With 3D bioprinting it is possible to manufacture such tissues, however, its biomechanical characteristics reduce its capabilities to be sutured. As a result, 3D.FAB, a French additive manufacturing platform, is developing a “living bandage” using 3D bioprinting and direct additive manufacturing. According to the platform’s project “STRESSKIN,” such technologies can be positioned in this field of regenerative and personalized medicine to address this issue.
What looks like a traffic grid filled with roundabouts is nothing of the sort: It’s actually a peek inside a tiny microchamber that models a complex system operating in many of our cells.
The December issue of Transplantation Direct contains a diverse set of transplantation articles. In pediatric transplantation, a Canadian study reports on study design and preliminary results from work aimed to personalize ("PersOnaliSing") immunosuppression in children and young adults. We also publish an interesting case report of graft loss due to thrombosis in a pediatric multivisceral transplant recipient. In liver transplantation, we highlight an article examining the value of bone scans in patients with pretransplant HCC, which challenges the current guidelines. We also have an infectious disease article relating to a liver transplant recipient case where hemophagocytic lymphohistiocytosis due to HHV-8 infection led to a life-threatening complication. Increasing lungs suitable for transplantation is the aim of a study testing warm ischemia time extension in pig lungs mimicking circumstances of "donation after circulatory death". Two studies from the UK are related to kidney transplantation: one looks at the impact of immunosuppression withdrawal after complete graft failure with regard to affecting future transplant possibilities, and a second UK study reports on outcomes from recipients with nondirected live donors. We appreciate these contributions, and look forward to yours in the near future.
Dr Peri Husen, Editorial Fellow, Transplantation.
Verbeek TA, Stine JG, Saner FH, Bezinover D.
Transplantation Direct. 2018;4:e403.
In this review, an expert panel analyzes the multifactorial cause of hypercoagulability in patients with end-stage liver disease (ESLD), delineating the effects of underlying liver diseases and treatment options of thrombotic events. Even though ESLD has traditionally been regarded as a model for coagulopathy, patients with cirrhosis rarely show unprovoked bleeding in comparison with patients treated with anticoagulants. In fact, these patients are not “auto-anticoagulated”, but rather predisposed to thrombosis during each stage of liver transplantation. The authors provide a thorough overview on the most recent literature, as well as recommendations for prophylaxis and treatment of thrombosis in this highly specialized patient population pre and post liver transplantation.
The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging countries.