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SERVING THE INTERNATIONAL TRANSPLANTATION COMMUNITY

TTS 2020 PROGRAM AND REGISTRATION NOW ONLINE

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As we wish to bring our Congress to the entire international transplantation community, and in everyone’s individual time zone, we developed a program and schedule that would allow all delegates to access the Congress programming during two time periods regardless of geographic region.

Visit www.tts2020.org for full details

TRANSPLANTATION - WEEK'S MOST DOWNLOADED PAPER

CORONAVIRUS (COVID-19) UPDATE DASHBOARD

The Transplantation Society (TTS) and our journal Transplantation have developed online resources to keep you informed on the Coronavirus (COVID-19) outbreak.

We are also requesting contributions and news from the transplant community to be sent to This email address is being protected from spambots. You need JavaScript enabled to view it. for inclusion on our resources page.

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In this dashboard, you will find links to TTS and other global and regional resources, as well as interactive maps, publications and webinars. We encourage you to explore this dashboard and share with your colleagues.

Website - www.tts.org/covid-19


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Editors and contributors to Transplantation have shared their thoughts on how they are dealing with the current crisis. While we understand that the information of today may be quite different tomorrow in this fast-moving pandemic, this report will open our forum of an international exchange on COVID for the transplant community.

Website - www.tts.org/txjcovid19

Please send your own contributions and news to This email address is being protected from spambots. You need JavaScript enabled to view it. for inclusion on our resources page.

«HOT OFF THE PRESS» RECENT PUBLICATIONS IDENTIFIED BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee
This week's selection made by: Enver Akalin


Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.

COVIDSurg Collaborative*
LANCET May 29, 2020 https://doi.org/10.1016/S0140-6736(20)31182-X

This is an international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. This article analyzes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8%. Pulmonary complications occurred in 51·2% of the patients; 30-day mortality in these patients was 38·0%. The authors reported risk factors for mortality.


Strategies for Liver Transplantation during the SARS CoV‐2 Outbreak Preliminary Experience from a Single Center in France.

Xavier Muller et al.
American Journal of Transplantation First published: 31 May 2020
https://doi.org/10.1111/ajt.16082

This article reports strategies and preliminary results in liver transplantation during the peak of the SARS‐CoV‐2 pandemic from a single‐center in France. The authors performed 10 successful liver transplantations during the peak of the pandemic with a short median intensive care unit stay (2,5 days), benchmark post‐transplant morbidity and no occurrence of SARS‐CoV‐2 infection during follow‐up.


Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study.

Matthew J Cummings, Matthew R Baldwin, Darryl Abrams, Samuel D Jacobson, Benjamin J Meyer, Elizabeth M Balough, Justin G Aaron,
Jan Claassen, LeRoy E Rabbani, Jonathan Hastie, Beth R Hochman, John Salazar-Schicchi, Natalie H Yip, Daniel Brodie, Max R O’Donnell
LANCET May 19, 2020
https://doi.org/10.1016/S0140-6736(20)31189-2

This article reviewed 1150 adults who were admitted to between March 2 and April 1, 2020, with laboratory-confirmed COVID-19, of which 257 (22%) were critically ill. As of April 28, 2020, 39% patients had died, 79% patients received invasive mechanical ventilation, 31% received renal replacement therapy. Older age, chronic heart and lung disease, high IL6 and D-dimer levels were associated with mortality.


Anakinra for severe forms of COVID-19: a cohort study.

Thomas Huet, Hélène Beaussier, Olivier Voisin, Stéphane Jouveshomme, Gaëlle Dauriat, Isabelle Lazareth, Emmanuelle Sacco, Jean-Marc Naccache, Yvonnick Bézie, Sophie Laplanche, Alice Le Berre, Jérôme Le Pavec, Sergio Salmeron, Joseph Emmerich, Jean-Jacques Mourad, Gilles Chatellier, Gilles Hayem
Lancet Rheumatol 2020 Published Online May 29, 2020
https://doi.org/10.1016/S2665-9913(20)30164-8

This article reports 52 consecutive patients in the anakinra group and 44 historical patients who were identified in the Groupe Hospitalier Paris Saint-Joseph COVID cohort study from March 24 to April 6, 2020. Admission to the ICU for invasive mechanical ventilation or death occurred in 13 (25%) patients in the anakinra group and 32 (73%) patients in the historical group (hazard ratio [HR] 0・22 [95% CI 0・11–0・41; p<0・0001). The treatment effect of anakinra remained significant in the multivariate analysis (HR 0・22 [95% CI 0・10–0・49]; p=0・0002).


Antibody responses to SARS-CoV-2 in patients with COVID-19.

Quan-Xin Long et al.
Nature Medicine
https://doi.org/10.1038/s41591-020-0897-1

This article reports acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT–PCR results and for the identification of asymptomatic infections.

IN THE NEWS

IN A MOLECULE, RESEARCHERS SEE POTENTIAL TO HELP ORGAN TRANSPLANTS THRIVE

May 28 - Scientists have made great strides in increasing success rates for organ transplants—at least through the first year after surgery. But a lingering long-term response of the recipient's immune system tends to erode the grafted tissue's health, and can eventually lead to organ failure.

READ THE FULL ARTICLE

NEW HUMAN-MOUSE CHIMERA IS THE MOST HUMAN YET

May 29 - A newly-created mouse-human embryo contains up to 4% human cells — the most human cells yet of any chimera, or an organism made of two different sets of DNA.

READ THE FULL ARTICLE

THE FUTURE OF DIABETES: IMPROVING ISLET TRANSPLANTATION

May 27 - This year, the U.S. Food and Drug Administration is expected to approve islet transplants as a treatment for people with type 1 diabetes. The transplants, which deliver insulin-making cells to replace those lost to the disease, have been classified as experimental in the United States since they were first performed more than 20 years ago.

READ THE FULL ARTICLE

INEQUITIES IN ACCESS TO KIDNEY TRANSPLANTATION EXIST EVEN WITH UNIVERSAL HEALTHCARE

May 28 - A new study has uncovered inequities in access to kidney transplantation in the UK despite its universal healthcare system. The findings appear in an upcoming issue of CJASN.

READ THE FULL ARTICLE

BEYOND COLD STORAGE: TECHNOLOGY DESIGNED TO KEEP ORGANS WARM, HELPS LIVER TRANSPLANT PATIENTS IN KEY STUDY

May 26 - Since the 1960s, cold storage emerged as the preferred method for organ preservation for transplantation, but it didn’t tick all the boxes — limitations such as the risk of early graft dysfunction still contribute to chronic complications. So an upgrade was in order. Instead of flushing and preserving the procured organ at roughly freezing temperatures, new technology actually keeps the organs warm and toasty for transplantation in a bid to improve organ accessibility and improve transplantation outcomes.

READ THE FULL ARTICLE

UPCOMING MEETINGS AND ANNOUNCEMENTS

11th International Pediatric Intestinal Failure and Rehabilitation Symposium

Virtual Town Hall — June 26, 2020

International Transplantation Science Meeting

ITS 2020 Meeting in Europe is postponed to 2022
ITS 2021 meeting in the San Diego area — October 17-20, 2021

After careful consideration, and in light of the ongoing Coronavirus developments, we’ve made the difficult decision to postpone the ITS 2020 Meeting in Europe to 2022. Stay tuned for dates and location.

We would like to take this opportunity to confirm that we will have the 2021 ITS meeting in the San Diego area from October 17-20, 2021.
Further details will be available this summer.

We look forward to hosting you in California next year.
Until then, stay safe and healthy!

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