The Editors of Transplantation and Transplantation Direct are seeking expressions of interest for the role of Editorial Fellow.
The Fellowship is designed for an early career professional in transplantation interested in being on the frontlines of Transplantation, the most cited journal in transplantation, and Transplantation Direct, our open access journal.
Dr. Jeremy R. Chapman, Editor-in-Chief, Transplantation
Reichart B, Längin M, Denner J,et al.
Transplantation: December 21, 2020 - Volume Online First
Despite ventricular assist device improvement over the past few years, heart transplantation is the only long-lasting treatment for terminal cardiac failure. Because the number of available human organs is and will remain forever far below the actual need, there is substantial mortality on the heart transplant waiting lists driving the search for an alternative biological solution. Perhaps out of sight of the majority of us, consistent success has been achieved in orthotopic transplantation of genetically modified pig hearts into baboons. Perhaps cardiac xenotransplantation is destined to become clinically applicable option that is justifiable for heart failure patients sooner than might be considered for the other organ transplants. In this overview the authors, who are well placed to address the issues of clinical cardiac xenotransplantation, discuss: the choice of genetically modified source pigs; microbiological and specific virological safety; optimized matching of source pig and recipient; treatment of the donor heart after explantation; selection of patients and importantly the regulatory framework that will be needed. It may not come as soon as some hope but the process is inching forward.
The participant will identify the impact of clinical research on patient outcomes in the area of transition from hospital to home and chronic illness care for parents of pediatric solid organ transplant recipients.
Dear Women in Transplantation and TTS members,
In the spirit of continuing to support transplantation professionals worldwide, Women in Transplantation (an Initiative of The Transplantation Society) is delighted to announce a series of webinars in collaboration with the Asian Society of Transplantation (an Affiliated Society of The Transplantation Society).
These webinars will take place on Thursday January 28th 2021 and Thursday February 25th 2021.
Women in Transplantation (WIT) initiative of The Transplantation Society will provide funding to an Early Career Researcher to support research focusing on sex and gender issues relevant to solid organ transplantation.
This initiative was made possible with support with One Lambda, a Thermo Fisher Scientific brand, and Sanofi, with each supporting one award.
The spectrum of studies includes basic, clinical and translational. This individual should have spent two years or less performing research relevant to solid organ transplantation since obtaining their last degree (PhD, MD, MSc, PharmD, or equivalent). This work may represent a continuation of current research or a novel aspect of work. The mentor should have expertise in transplantation or immunology but need not be an investigator with known expertise in gender or sex.
In this systematic review, a search of the MEDLINE and medRxiv databases was conducted to assess the diagnostic accuracy of saliva nucleic acid amplification testing (NAAT) for COVID-19. The search strategy yielded 385 references, and 16 unique studies were identified for quantitative synthesis. Eight peer-reviewed studies and 8 preprints were included in the meta-analyses (5922 unique patients). There was significant variability in patient selection, study design, and stage of illness at which patients were enrolled. Fifteen studies included ambulatory patients, and 9 exclusively enrolled from an outpatient population with mild or no symptoms. In the primary analysis, the saliva NAAT pooled sensitivity was 83.2% (95% credible interval [CrI], 74.7%-91.4%) and the pooled specificity was 99.2% (95% CrI, 98.2%-99.8%). The nasopharyngeal swab NAAT had a sensitivity of 84.8% (95% CrI, 76.8%-92.4%) and a specificity of 98.9% (95% CrI, 97.4%-99.8%). Results were similar in secondary analyses. These results suggest that saliva NAAT diagnostic accuracy is similar to that of nasopharyngeal swab NAAT, especially in the ambulatory setting. These findings support larger-scale research on the use of saliva NAAT as an alternative to nasopharyngeal swabs.
This article compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Bivariate analysis found transplant status, age, gender, race/ ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR < 60 mL/min/1.73 m2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99–1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03–1.74, p = .027).
This study extracted data from the electronic health record on hospitalized patients with SARS-CoV-2 testing at six hospitals from March 4th through September 9th, 2020. The outcomes between SARS-CoV-2 positive KTR and controls: SARS-CoV-2 positive non-KTR, SARS-CoV-2 negative KTR and SARS-CoV-2 negative non-KTR were compared. Of 31,540 inpatients, 3213 tested positive for SARS-CoV-2. There were 32 SARS-CoV-2 positive and 224 SARS-CoV-2 negative KTR. SARS-CoV-2 positive KTR had higher ferritin levels [1412 (748,1749) vs. 553 (256,1035), p < 0.01] compared to SARS-CoV-2 positive non-KTR. SARS-CoV-2 positive KTR had higher rates of ventilation (34% vs. 14%, p < 0.01 vs. 5%, p < 0.01) vasopressor use (41% vs. 16%, p < 0.01, vs. 17%, p < 0.01, vs. 12%, p < 0.01) and acute kidney injury (AKI) (47% vs. 15%, p < 0.01, vs. 23%, p < 0.01, vs. 10%, p < 0.01) compared to SARS-CoV-2 positive non-KTR, SARS-CoV-2 negative KTR, and SARS-CoV-2 negative non-KTR, respectively. SARS-CoV-2 positive KTR continued to have increased odds of ventilation, vasopressor use and AKI compared to SARS-CoV-2 positive non-KTR independent of Elixhauser score, Black race and baseline eGFR. Mortality was not significantly different between SARS-CoV-2 positive KTR and non-KTR, but there was a notable trend towards higher mortality in SARS-CoV-2 positive KTR (25% vs. 16%, p=0.15, respectively).
TID has expanded their "Guidance on Coronavirus Disease 2019 (COVID-19) for Transplant Clinicians” to include a new section (Section #7) entitled "Guidance Focused Review on SARS-CoV-2 Vaccines in Transplant Recipients
Jan. 10 - Arthroscopic matrix-assisted autologous chondrocyte transplantation for articular cartilage defects of the knee may offer positive, long-lasting results with limited failures or reinterventions, according to published results.
Jan. 11 - A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at disproportionately higher rates than non-Hispanic Black patients. However, researchers went a step further as they identified key reasons for that disparity: disproportionate access to private health insurance, travel distance to transplant centers, and a potential lack of knowledge among both practitioners and patients about available options.
Jan. 14 - Heart transplantation is heralded as the most effective therapy for patients with end-stage heart failure. Life expectancy post-transplant is now at an all-time high with heart transplant recipients expected to live for 11 years.1 It is undoubtedly one of the most significant and life-changing medical interventions, covering a vast canvas of emotions in addition to its physical implications.
Jan. 12 - Since early 2019, COVID-19 has significantly impacted the world, changing the landscape of health care dramatically. Organ transplant recipients are dying from this virus at a disproportionately higher rate than the rest of the population. They need to be protected with vaccinations as soon as possible.
Jan. 14 -Primate model studies show the procedure can be done safely and without losing eye function. Which patients may benefit first? New study results bring clinicians one step closer to treating degenerating vision, and even blindness, with stem cell therapy.