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Participate by: February 15, 2021

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«HOT OFF THE PRESS»
RECENT PUBLICATIONS IDENTIFIED BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Enver Akalin.

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera

Alexander Muik et al.
Science. 29 Jan 2021:DOI: 10.1126/science.abg6105

Recently, a new SARS-CoV-2 lineage called B.1.1.7 (variant of concern: VOC 202012/01) emerged in the United Kingdom that was reported to spread more efficiently and faster than other strains. This variant has an unusually large number of mutations with 10 amino acid changes in the spike protein, raising concerns that its recognition by neutralizing antibodies may be affected. This article tested SARS-CoV-2-S pseudoviruses bearing either the Wuhan reference strain or the B.1.1.7 lineage spike protein with sera of 40 participants who were vaccinated in a previously reported trial with the mRNA-based COVID-19 vaccine BNT162b2. The immune sera had slightly reduced but overall largely preserved neutralizing titers against the B.1.1.7 lineage pseudovirus. These data indicate that the B.1.1.7 lineage will not escape BNT162b2-mediated protection.

Recent updates in the clinical trials of therapeutic monoclonal antibodies targeting cytokine storm for the management of COVID-19

Shikha Patel et al.
HELIYON, https://doi.org/10.1016/j.heliyon.2021.e06158.

This review article compiled all therapeutic mAbs targeting cytokine storm, which are in clinical trials for its repurposing in the management of COVID-19. Compilation of clinical trial data indicated that therapeutic monoclonal antibodies targeting interleukins (IL-6, IL-1ra, IL-8, IL-1β, IL-17A, IL-33), interferon-gamma, tumor necrosis factor-alpha, P-selectin, connective tissue growth factor, plasma kallikrein, tumor necrosis factor superfamily 14, granulocyte macrophage colony stimulating factor, colony stimulating factor 1 receptor, C-C chemokine receptor type 5, cluster of differentiation 14 and 147, vascular endothelial growth factor, programmed cell death protein-1, Angiopoietin - 2, human factor XIIa, complementary protein 5, natural killer cell receptor G2A, human epidermal growth factor receptor 2, immunoglobulin-like transcript 7 receptor, complement component fragment 5a receptor and viral attachment to the human cell were under investigation for management of severely ill patients with COVID-19. Among these, about 65 clinical trials are targeting IL-6 inhibition as the most promising one and Tocilizumab, an IL-6 inhibitor is considered to be the potential candidate to treat cytokine storm associated with the COVID-19.

TTS-ILTS Paired Transplant Centers Program
Application Deadline Extended to February 24th, 2021

The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging economies.

JUST RELEASED - TRANSPLANTATION - FEBRUARY ISSUE

An issue for a northern winter or the southern summer sun! Perhaps an issue to kick start your research with ideas from these papers. Young women with renal transplants at risk of cardiac disease, A new antibody to treat ABMR. An RCT or two and some important papers on the heart in Liver transplantation and management of Lung transplantation. A great review of the role of NK cells and also some important reflections on multi drug resistant organisms.

CLICK HERE TO ACCESS THIS ISSUE

TTS MEMBERS - CLICK HERE TO SIGN-IN FOR OPEN ACCESS THROUGH TTS.ORG

TRANSPLANTATION - WEEK'S MOST DOWNLOADED PAPER

Transplantation Editorial Fellowship

Call for Applications

The Editors of Transplantation and Transplantation Direct are seeking expressions of interest for the role of Editorial Fellow.

The Fellowship is designed for an early career professional in transplantation interested in being on the frontlines of Transplantation, the most cited journal in transplantation, and Transplantation Direct, our open access journal.

CLICK HERE FOR FULL DESCRIPTION

TTS and TTS Sections News

SPLIT Allied Health Professionals Webinar

Thursday, February 11, 2020 - 1:00PM EST (Montreal time)

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TITLE: Hospital Discharge Following Transplantation: There Is No Place Like Home

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The participant will identify the impact of clinical research on patient outcomes in the area of transition from hospital to home and chronic illness care for parents of pediatric solid organ transplant recipients.

Objectives:
  1. Associations between hospital processes and post-discharge outcomes.
  2. Challenges experienced by families of children with complex medical conditions as they transition home from the hospital.
  3. Strategies to improve the discharge transition for transplant families.

CLICK HERE TO SIGNUP AND LEARN MORE

Women in Transplantation in Asia • Webinar Series

Update: Signup Required (Free)

Thursday February 25th 2021

Dear Women in Transplantation and TTS members,

The Asian Society of Transplantation (AST - myasot.org) in collaboration with the TTS Women in Transplantation (WIT) initiative are hosting two webinars on Gender Disparity in Transplant in Asia.

Thursday, January 28, 2021 (19:00 Seoul / Tokyo time - GMT+9)

Click here for more information

New Two-Year WIT Fellowship Grant Program

Letter of intent is due on March 1, 2021

Women in Transplantation (WIT) initiative of The Transplantation Society will provide funding to an Early Career Researcher to support research focusing on sex and gender issues relevant to solid organ transplantation.

This initiative was made possible with support with One Lambda, a Thermo Fisher Scientific brand, and Sanofi, with each supporting one award.

The spectrum of studies includes basic, clinical and translational. This individual should have spent two years or less performing research relevant to solid organ transplantation since obtaining their last degree (PhD, MD, MSc, PharmD, or equivalent). This work may represent a continuation of current research or a novel aspect of work. The mentor should have expertise in transplantation or immunology but need not be an investigator with known expertise in gender or sex.

Click here to read the statement

Members were emailed their invoices a month ago.
If you are not a member click the Join TTS button below!


IN THE NEWS

Icelandic man receives world's first double-arm-and-shoulder transplant

Jan. 22 - An Icelandic man who got the world’s first double-shoulder-and-arm transplant is recovering well after the operation, two decades after the accident that cost him both limbs, doctors have said.

READ THE FULL ARTICLE

SARS-CoV-2 genomic RNA in corneal transplantation: Are corneal transplantations safe?

Jan. 27 - According to investigators, a lack of definitive knowledge about the presence of SARS-CoV-2 in corneal tissues has resulted in the recommendation to avoid using corneal tissue for transplantation when the tissue was obtained from donors with COVID-19 that had been confirmed or those who were exposed to COVID-19.

READ THE FULL ARTICLE

Survival Benefit Seen From Transplant in Older Patients With Myelodysplastic Syndrome

Jan. 25 - In older patients with myelodysplastic syndrome (MDS) and a suitable HLA-matched donor, hematopoietic cell transplantation (HCT) improves survival even among those with high-risk features, according to a multicenter study that included a control group.

READ THE FULL ARTICLE

How blood stem cells maintain their lifelong potential for self-renewal

Jan. 27 - A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now discovered in mice that cells in the so-called "stem cell niche" are responsible for this: Blood vessel cells of the niche produce a factor that stimulates blood stem cells and thus maintains their self-renewal capacity. With the decades of life, the production of this factor ceases and blood stem cells begin to age.

READ THE FULL ARTICLE

Frailty often coexists in kidney transplant candidates, care partners

Jan. 28 - Patients categorized as frail and who were undergoing evaluation for kidney transplantation were “more likely” to have care partners who were also frail, according to a study.

READ THE FULL ARTICLE


UPCOMING MEETINGS AND ANNOUNCEMENTS

39th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (TSANZASM 2021)

March 14-16, 2021 • Virtual

International Symposium on Benign and Malignant Tumors in Liver With or Without Cirrhosis

June 24-25, 2021 • Kızılcahamam-Turkey

17th Congress of the Intestinal Rehabilitation and Transplant Association (CIRTA 2021)

June 30 - July 2, 2021 • Auckland, New Zealand
Abstract Submission is now open!

CLICK HERE TO VISIT THE WEBSITE

The 17th Congress of The Asian Society of Transplantation (CAST 2021)

July 25-28, 2021 • Virtual

17th Congress of the Middle East Society For Organ Transplantation (MESOT 2021)

September 3-5, 2021 • AMMAN-JORDAN
SAVE THE DATE!

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