Statement on COVID-19 Vaccination in Solid Organ Transplant Recipients

New Endorsing Organizations Added!

Recently, multiple studies have been published examining the response to SARS-CoV-2 mRNA-based vaccines in solid organ transplant (SOT) recipients.(1-7) Overall, these have demonstrated reduced antibody responses to vaccine when compared with reports involving the general public.


Read the full statement

The low antibody response rate is concerning but not unexpected as SOT recipients have lower rates of immune responses to other vaccines as well.(8) Further data are needed to evaluate B- and T- cellular responses in SOT recipients after SARS-CoV-2 vaccination and to assess vaccine effectiveness particularly for protection against severe COVID-19 as a clinical end-point. Previous experience with influenza vaccination in transplant patients has demonstrated reduced influenza-related lower respiratory tract disease and hospitalization despite low antibody response.(9, 10). While breakthrough cases of COVID-19 after partial or full vaccination in SOT recipients may occur, it is important to recognize that we may be preventing more cases or reducing severity through vaccination.(11, 12) Thus, we strongly caution against concluding that low antibody response rate to SARS-CoV-2 vaccination will lead to reduced clinical effectiveness until more information is available. These results should not prompt or encourage vaccine hesitancy in SOT recipients.

Immunosuppressed patients are known to have prolonged viral shedding of actively replicating virus which may promote the development of viral variants.(13) Additionally, there are data to suggest worse outcomes in SOT recipients with COVID-19 compared to the general population.(14) The effect of immunization on duration of viral shedding and clinical outcomes remains unknown for this population.

Until more complete data are available, we urge:

  • Pre-transplant vaccination of all SOT candidates as a priority whenever feasible.
  • Continued SARS-CoV-2 vaccination in SOT recipients and priority for vaccination of their household members and caregivers to reduce exposure risk for these vulnerable patients.
  • Continuation of a stable immunosuppression regimen at the time of vaccination to avoid the risk of organ rejection until more comprehensive data are available.
  • Continued adherence of all transplant recipients to protective measures including masking and social distancing regardless of vaccination status.
References (click to view)
  1. Boyarsky BJ, Werbel WA, Avery RA, Tobian AAR, Massie AB, Segev DL, Garonzik-Wang JM: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients. JAMA 2021.
  2. Benotmane I, Gautier-Vargas G, Cognard N, et al.: Weak anti-SARS-CoV-2 antibody response after the first injection of an mRNA COVID-19 vaccine in kidney transplant recipients. Kidney Int 2021.
  3. Sattler A SE, Weber U, Potekhin A, Bachmann F, Budde K, Storz E, Proß V, Bergmann Y, Thole L, Tizian C, Hölsken O, Diefenbach A, Schrezenmeier H, Jahrsdörfer B, Zemojtel T, Jechow K, Conrad C, Lukassen S, Stauch D, Lachmann N, Choi M, Halleck F, Kotsch K. MedRxv. doi: https://doi.org/10.1101/2021.04.06.21254963. Accessed 4/19/2021: Impaired Humoral and Cellular Immunity after SARS-CoV2 BNT162b2 (Tozinameran) Prime-Boost Vaccination in Kidney Transplant Recipients.
  4. Yi SG, Knight RJ, Graviss EA, et al.: Kidney Transplant Recipients Rarely Show an Early Antibody Response Following the First COVID-19 Vaccine Administration. Transplantation 2021.
  5. Peled Y RE, Lavee J, Sternik L, Segev A, Wieder-Finesod A, Mandelboim M, Indenbaum V, Levy I, Raanani E, Lustig Y, Rahav G: BNT162b2 vaccination in heart transplant recipients: clinical experience and antibody response. J Heart Lung Transplant 2021.
  6. Narasimhan M ML, Clark AE, Usmani A, Cao J, Raj E, Torres F, Sarode R, Kaza V, Lacelle C, Muthukumar A: Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines. medRxiv 2021.
  7. Shostak Y SN, Heching M, Rosengarten D, Shtraichman O, Shitenberg D, Amor SM, Yahav D, Zvi HB, Pertzov B, Kramer MR: Early humoral response among lung transplant recipients vaccinated with BNT162b2 vaccine. The Lancet Resp Med 2021.
  8. Eckerle I, Rosenberger KD, Zwahlen M, Junghanss T: Serologic vaccination response after solid organ transplantation: a systematic review. PLoS One 2013;8:e56974.
  9. Kumar D, Ferreira VH, Blumberg E, et al.: A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients. Clin Infect Dis 2018;67:1322-9.
  10. Pinana JL, Perez A, Montoro J, et al.: Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study. Clin Infect Dis 2019;68:1894-903.
  11. Basic-Jukic N, Jelicic I: SARS-CoV-2 infection after two doses of mRNA vaccine in renal transplant recipients. Transpl Infect Dis 2021:e13628.
  12. Wadei HM GT, Leoni JC, Shah SZ, Aslam N, Speicher LL., COVID-19 infection in Solid Organ Transplant Recipients after SARS-CoV-2 vaccination. Am J Transplant 2021.
  13. Aydillo T, Gonzalez-Reiche AS, Aslam S, et al.: Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer. N Engl J Med 2020;383:2586-8.
  14. Nair V, Jandovitz N, Hirsch JS, et al.: An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients. Am J Transplant 2020.

Memorial Service for Agnes M. Isabey-Azimzadeh

Dear Colleagues,

Agnès Azimzadeh passed away on March 15, 2021, after a courageous battle with intestinal cancer. The scientific and clinical transplant communities she touched at Massachusetts General Hospital, University of Maryland, and around the world join her family in celebrating her life, and mourning her premature loss.

On Saturday, May 29th at 10:00AM EDT, her professional colleagues and former trainees will gather virtually to celebrate Agnes's life and her scientific contributions. A link to the gathering can be found at:

All program attendees are STRONGLY ENCOURAGED to pre-register for the event. Persons who wish to make scheduled remarks in the official program are asked to communicate with Dr. Richard N. Pierson III, at rpierson@mgh.harvard.edu.

Starting June 14, Join us for the TTS Masterclass Series

Delivered by the world’s best known and regional experts, each Masterclass includes presentations by an international and a regional expert to bring perspective to the topic, highlight differences and opportunities, and bolster active discussions.

Highlighted Tweets


Upcoming Webinars


Reminders ...In Case you missed it!

IXA-CTRMS are pleased to announce the extension of the abstract submission deadline until June 1, 2021.

We thank all authors from across the world who have already completed their submission. Please note that there will be no further extension to the deadline.

For guidelines and to submit your abstract click here

The course is open to all participants who want to learn about ethics in transplantation, the DOI and the DICG

DICG Highlighted Video from April Newsletter


Highlighted News

New Technique Grows Realistic Bone in a Dish

June Issue - Laboratory-grown organoids—tiny cellular structures that mimic an organ's anatomy and functions—are becoming increasingly useful in medical research.

The International Society for Stem Cell Research relaxed the famous 14-day rule on culturing human embryos in its latest research guidelines

U.K. Study Shows Power of Digital Contact Tracing for COVID-19

May 20 - For many people who’ve had COVID-19, the infections were thankfully mild and relatively brief. But these individuals’ immune systems still hold onto enduring clues about how best to neutralize SARS-CoV-2, the coronavirus that causes COVID-19. Discovering these clues could point the way for researchers to design highly targeted treatments that could help to save the lives of folks with more severe infections.

Hot off the Press 

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Dr. Enver Akalin.

Diverse Functional Autoantibodies in Patients with COVID-19

Eic Y. Wang et al.
Nature, 2021 May 19. doi: 10.1038/s41586-021-03631-y. Online ahead of print. PMID: 34010947
This article used a high-throughput autoantibody (AAb) discovery technique called Rapid Extracellular Antigen Profling (REAP)7 to screen a cohort of 194 SARS-CoV-2 infected COVID-19 patients and healthcare workers for autoantibodies against 2,770 extracellular and secreted proteins (the “exoproteome”). The results showed that COVID-19 patients exhibit dramatic increases in autoantibody reactivities compared to uninfected controls, with a high prevalence of autoantibodies against immunomodulatory proteins including cytokines, chemokines, complement components, and cell surface proteins. These autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signaling and by altering peripheral immune cell composition, and found that murine surrogates of these autoantibodies exacerbate disease severity in a mouse model of SARS-CoV-2 infection. Analysis of autoantibodies against tissue-associated antigens revealed associations with specific clinical characteristics and disease severity. In summary, these findings implicate a pathological role for exoproteome-directed autoantibodies in COVID-19 with diverse impacts on immune functionality and associations with clinical outcomes.

Outcomes of Coronavirus Infectious Disease -19 (COVID-19) in Solid Organ Transplant Recipients: A Propensity Matched Analysis of a Large Research Network

Hadi YB et al,
Transplantation. 2021 Feb 5. doi: 10.1097/TP.0000000000003670. Online ahead of print. PMID: 33988341
This study used a multicenter federated research network to compare clinical outcomes of COVID-19 in patients with SOT to a propensity matched cohort of patients without SOT. 2,307 SOT recipients and 231,047 non-transplant patients with COVID-19 were identified. Transplant patients were more likely to be male, older, have a BMI >30kg/m2, and have comorbid hypertension, diabetes, nicotine dependence, heart failure and ischemic heart disease compared to non-transplant group (p-value <0.05). 1:1 matching was performed for diabetes, hypertension, chronic lung diseases, race, nicotine dependence, heart failure, ischemic heart disease and gender. There was no difference in the composite outcome of intubation or mechanical ventilation at 30 days (RR 1.04, 95% CI: 0.86–1.26) or 60 days (RR 1.03, 95% CI: 0.86-1.24) between the two groups. Hospitalization rate was higher in the transplant cohort (30.97% vs 25.47%, RR 1.22, 95% CI: 1.11-1.34). There was no difference in mortality at 30 days (6.45% vs 5.29%, RR 1.22, 95% CI: 0.88–1.68) or 60 days post diagnosis (RR 1.05, 95% CI: 0.83–1.32). More patients in the SOT group developed acute renal injury compared to non-SOT cohort (24.73% vs 14.29%; RR 1.73, 95% CI: 1.53-1.96).

IN THE NEWS 


Social

Contact

Staff Directory
+1-514-874-1717
info@tts.org

Address

The Transplantation Society
International Headquarters
505 Boulevard René-Lévesque Ouest
Suite 1401
Montréal, QC, H2Z 1Y7
Canada