Transplantation Direct - December 2021 Issue

JUST RELEASED - TRANSPLANTATION DIRECT - DECEMBER ISSUE

Transplantation Direct has published the December issue, which covers various topics in transplantation. For those interested in kidney transplantation, we have articles on CXCL13 as a biomarker of germinal cell - DSA - activity, the dynamics of immune responses in dialysis and transplant recipients, U.S. obesity trends (by region) in end-stage kidney disease patients, and an extraordinary case of a type 1 diabetes patient living long term into their 8th decade after transplantation without diabetic kidney disease. In pediatric kidney transplantation, urinary biomarkers of allograft injury are proposed. We also have a report on the occurrence of orthostatic hypertension following simultaneous kidney pancreas versus kidney alone transplantation. In liver transplantation, metabolic biomarkers for NAFLD are proposed, experience with transplantation in patients with acute on chronic liver failure is reported, and the value of dual lactate clearance measurements in DCD livers during normothermic machine perfusion is demonstrated. For the heart transplant community, health-related quality-of-life is assessed between older patients awaiting transplantation with or without mechanical circulatory support and caregivers. In other transplantation studies we there is an article on recognizing cases of demodex folliculitis in stem cell transplant patients. With COVID-19 still weighing heavily on our minds, there is also a report on discordance in cellular vs humoral responses following vaccination in kidney and liver transplant recipients. For full details of this issue, visit our open access Transplantation Direct website.

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Webinar Spotlight - December 16, 2021 - Open to all transplant professionals


ISN-TTS Webinar - December 13

Presentation Objectives:
  1. To understand the global transplant needs and the current access of patients to transplantation
  2. To identify factors that may impact the development of deceased donor transplantation
  3. To describe strategies that can contribute to increasing the availability of organs from deceased donors
Transplantation is the best and frequently the unique treatment for patients with organ failure that primarily results from non-communicable diseases, which burden is increasing in nearly all countries throughout the world. According to data from the Global Observatory on Organ Donation and Transplantation (GODT), close to 154,000 organ transplants were performed in 2019. Yet the World Health Organization (WHO) estimates that this constitutes only 10% of the organs needed for patients diagnosed with end-stage organ failure. The disparity between supply and demand of organs has likely been exacerbated during 2020 due to the COVID-19 pandemic, with an estimated decline of 15% in global transplant activities. Countries have also unequally developed organ transplantation, not only quantitatively, but also in terms of reliance upon living versus deceased donors.

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The WHO has called countries to pursue self-sufficiency in transplantation by decreasing the burden of diseases treatable with transplantation and by increasing the availability of organs, with priority given to maximizing deceased donation and ensuring the protection of living donors. Depending on the level of human development, health priorities in transplantation may range from protecting the resident population from exploitation to developing deceased donation to its maximum therapeutic potential. The fundamental pillar of deceased donation is the organization of a multidisciplinary process of high complexity to ensure the systematic identification of individuals who die or about to die in conditions consistent with organ donation and their transition to actual donors. The engagement of the critical care community, the creation of a donor coordination network, efforts in professional training and continuous evaluation of performance are key elements of a successful deceased donor program. The progressive decline in the incidence of brain death, the changing profile of potential donors and the emergence of new end-of-life care practices make mandatory the search for novel strategies to further increase organ availability from the deceased: i) the transplantation of organs from expanded criteria and non-standard risk donors; ii) the routine consideration of intensive care to facilitate organ donation; iii) the promotion of donation after the circulatory determination of death. In situ and ex-situ preservation measures will help to improve post-transplant outcomes in these new challenging scenarios. With such a comprehensive approach, not only patients will gain better access to transplantation, but many other dying patients will be given the opportunity to donate their organs if this is consistent with their principles and values.



Women in Transplantation News and Upcoming Event


Women in Transplantation is delighted to announce its second Fellowship Grant for Research in Gender and Sex in Transplantation for the period 2022-2024.

With the support of Industry Partners, WIT will provide funding to support research to early career researchers that contributes to the the Grant Recipient's understanding of the impact of sex and gender issues in solid organ transplantation and immunology. The spectrum of studies includes epidemiological, basic, clinical and translational.

Please go to www.tts-wit.org/2022_fellowship_grant or email Katie Tait, TTS Special Initiative Manager at katie.tait@tts.org for more information.

Letters of Intent Deadline: February 1, 2022

Application Deadline: April 1, 2022.

Supporting Partners

Women in Donation Event

Women in Transplantation (WIT) programming and events have covered many critical issues over the last decade, including a focus on gender in careers in transplantation.


IRTA Section Webinar


International Forum - Recordings Now Available


SPLIT 2021 Annual Meeting Recordings Now Available!


Latest Video Additions


TTS-ILTS Paired Transplant Centers Program


The TTS-ILTS Paired Transplant Centers Program is now accepting applications!

The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging economies.

Application Deadline: January 1st, 2022

WHO
An experienced transplant center in the developed world is paired with an emerging transplant center to facilitate vital multidisciplinary training and an exchange of knowledge and expertise.
WHY
The project aims to benefit both centers. The supporting center (SC) is involved in global health, and promotes ethical and competent transplantation in regions of the world with limited or no current access to transplantation. The emerging center (EC), connects with a multidisciplinary team of experts in transplantation from a world-leading center.
STEPS
Progressive steps associated with increasing funding as the partnership between the EC and SC grows.
GOAL
The ultimate goal is for Level 3 centers to graduate and become true local centers of excellence for regional training and support.

New Members Added in November 2021

We wish a warm welcome to November's new TTS members and we look forward to making new connections together.

Mulugeta Adhanom
Kohat Saint Paul's Hospital Millennium Medical College
Addis Ababa, Ethiopia

Jorge Arroyo Orvananos
Hospital Infantil de México Federico Góme
Mexico City, Mexico

Piotr Domagala
Medical University of Warsaw
Warsaw, Poland

Holly Foote
NYU Langone
New York, United States

Latifa Gueddah
Security Forces Hospital – Riyadh
Riyadh, Saudi Arabia

Wenyu Jiao
Columbia University
New York, United States

Aine Lynch
The Hospital for Sick Children
Toronto, Canada

Mayra Matias Carmona
Centro Medico Nacional 20 de Noviembre
Mexico City, Mexico

Maks Mihalj
University Hospital of Bern
Bern, Switzerland

Andreea Moga
Grigore Alexandrecu Children's Hospital Bucharest
Bucharest, Romania

Natalia Yanet Panero Schipper
Hospital de Pediatría Garrahan
Bueanos Aires, United States

Madhukar Patel
University of Texas Southwestern Medical Center
Dallas, United States

Kim Piburn
Stanford University School of Medicine
Santa Clara, United States

Ratnagiri Ravikumar
MGM Hospital Chennai
Chennai, India

Nancy Rodig
Boston Children's Hospital
Boston, United States

Kristen Sgambat
Children's National Pediatricians & Associates Silver Spring
Silver Spring, United States

Ahmed Twahir
Parklands Kidney Centre Ltd
Nairobi City, Kenya

Monica Westley
Marymount California University
Palos Verdes Estates, United States


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