Packed full of interest for everyone, this issue ranges from a new islet isolation system and better machine perfusion techniques, to long term consequences and risk factors in pancreas, lung, heart and liver transplantation. A brilliant review of tissue resident memory T Cells is just one of a number of fascinating basic science papers this month. Pregnancy after kidney transplantation remains an important goal for many patients and this issue has useful data and advice for those counselling such patients.
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Repairing and Regenerating Organs for Transplantation Has Become a Reality #TBT
The research described in this issue of Transplantation and summarized in the commentary by Baan highlights the latest developments in the field of tissue engineering, repair and regeneration for organ transplantation.Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant #OpenAccess #TransplantTwitter
Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR] and antibody-mediated rejection [AMR]), chronic lung allograft dysfunction (CLAD), or infection (INFXN). Previous research indicates that donor-derived cell-free DNA (dd-cfDNA) is a promising noninvasive biomarker for the detection of AR and allograft injury. Our aim was to validate a clinical plasma dd-cfDNA assay for detection of AR and other allograft injury and to confirm and expand on dd-cfDNA and allograft injury associations observed in previous studies.The Transplantation Society
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