




The February issue of Transplantation Direct covers a full spectrum of topics in transplantation. We feature a several articles in kidney transplantation including an investigation into carboxypeptidase polymorphism associations with allograft loss, a report on the longer-term effects of delayed graft function in recipients, outcomes with combined anti-CD20 and anti-CD38 therapy in regard to FSGS recurrence after transplantation, insight into marked variations in center-specific acceptance of suboptimal donor kidney offers, testing the impact of early elevations in dd-cfDNA on long-term transplant outcomes, and a report on the suitability of wearable digital health devices in older transplant candidates. In liver transplantation, we have a study reporting on predictions of tolerance using microRNA profiling in pediatric transplant recipients. We also spotlight articles in the field of lung transplantation, including results from a prospective study to use dd-cfDNA measurements in lieu of transbronchial biopsies in the first post-transplant year, testing von Willebrand factor in lung microvascular endothelial cells as a surrogate for improving pre-transplant organ conditioning, and an evaluation of variability in clinical lung transplant practices in Canada. For the heart transplant community, we have an article on detection of peripheral blood transcriptomic signatures that identify rejection. On other topics, another article focuses on the importance of MHC matching in pigs with regard to inducing tolerance to VCA transplants after hematopoietic stem cell transplantation. We also have a pig model study on the use of hypothermic machine perfusion to improve pancreas preservation before transplantation. And, finally, for the hematologists, we have a report on the evaluation of intensified treosulfan – fludarabine conditioning with thiotepa addition in older or comorbid patients that have an active myeloid neoplasm undergoing allo-stem cell transplantation. We welcome you to this full slate of articles, which can be accessed in their entirety on our Transplantation Direct website.
Federal funding, particularly from the National Institutes of Health, plays a crucial role in advancing transplantation research. This support has helped lay the groundwork for significant progress in understanding transplantation and alloimmunity. The study highlights the achievements made possible through federal dollars, emphasizing the transformation of innovative ideas into clinical applications. However, it also points out the ongoing challenges and unmet needs in the field, suggesting that continued investment is essential for further breakthroughs and improvements in transplantation outcomes.
In 2026, three Officer positions will be vacated and 5 of the 14 Councilors-at-large representing the Regions will be changing. The elections will take place in early 2026 and those elected will assume their new roles starting at the 2026 TTS Congress in Sydney.







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