The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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Transplantation Direct - August Issue now available

LargeRollover.01845228 201808000 00000.CVThe August issue of Transplantation Direct covers several topics in transplantation. In kidney transplantation, KDRI and Leuven score predictors of allograft survival are compared for utility; another study looks at celiac-like duodenopathy in the differential diagnosis of MPA-associated diarrhea. Studies in lung transplantation report on viral respiratory tract infections and chronic allograft dysfunction, and on the occurrence and sequelae of hypogammaglobinemia; both studies focus on data in the first year posttransplantation. In intestinal transplantation, we include two reports: one investigation looks at the occurrence and impact of cases requiring dialysis or kidney transplantation, and the other study reports on results from patients receiving transplants from an identical twin. The growing problem of posttransplant malignancy and increasing use of checkpoint inhibitors for treatment is examined; a case of liver allograft failure is reported with nivolumab treatment, and a review of the literature of additional cases is provided. Regarding the topic of organ donation, we have a survey analysis devoted to examining attitudes of potential donors with stage 5 chronic kidney disease. We hope that you find this issue both engaging and stimulating.

 

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Ground-breaking study tests whether rejected livers can be made viable for transplantation

August 2 - A ground-breaking study is underway at the University of Birmingham and Queen Elizabeth Hospital Birmingham to establish if livers that have been rejected for transplantation can be made viable by using a liver perfusion machine.

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Should Australia change its organ donation laws? | 60 Minutes Australia

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Dr Dominique Martin, an expert in the ethics of organ donation, tells 60 Minutes that while recipients and donor families knowing each other can be a wonderful experience – it's not without pitfalls

WATCH The INTERVIEW

HighlightED ARTICLE - Transplantation Journal
Effects of Kidney Transplantation on Labor Market Outcomes in Sweden

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CLICK HERE TO READ THIS Article

Australia - Innovative dialysis system awarded $2.2 million

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New South Wales Minister for Health and Medical Research The Hon Brad Hazzard has announced Ellen Medical Devices, the developer of The George Institute's affordable dialysis system, as a recipient of a grant from the 2018 NSW Medical Devices Fund.

The affordable dialysis system has the potential to save millions of lives as an innovative and affordable device which costs under $1,000 to build and $5 a day to run, improving access to the life-saving treatment for vulnerable populations.

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HighlightED ARTICLE - Transplantation Direct

Long-term Prognosis and Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation: A Single-Center Experience.

Submitted by Dr Peri Kocabayoglu, Editorial Fellow, Transplantation.

Ueda Y, Kaido T, Okajima H, et al.  Transplant Direct. 2017;3;e334.

For patients with primary sclerosing cholangitis (PSC) as the underlying cause of end-stage liver disease, liver transplantation (LT) provides the only life-saving treatment. However, recurrence of the disease is frequent. Multiple risk factors appear to play a role.

In this sinlge-center retrospective chart review of 45 patients transplanted at Kyoto University from 1996 – 2015, Ueda and coworkers present risk factors for PSC recurrence and graft survival. 39/45 patients received a living-donor LT, 2/45 a deceased donor, and 4/45 a domino LT. Factors that could predict PSC recurrence were analyzed by comparing patients with (n=16) and without (n=24) PSC recurrence; patients with an arterial thrombosis or those who received an ABO-incompatible LDLT were excluded from the analysis. The graft survival rates were 55.4% at 5 years and 32.8% by all patients in the cohort. PSC recurrence was diagnosed in 40% of patients by 30 months after transplantation (median, range 9-70 months).
Risk factor for graft failure in a univariate analysis included: age < 30 years at the time of PSC diagnosis (P = 0.005), female donor (P = 0.029), HLA-DR15 positivity (P = 0.032), and bacteremia within 1 year after liver transplantation (P = 0.014). In a multivariate analysis, age < 30 years at time of PSC diagnosis (HR, 3.77; 95% CI, 1.28-11.1; P = 0.016) and bacteremia within 1 year after liver transplantation (HR, 2.38; 95% CI, 1.07-5.30; P = 0.034) had been identified as independent predictors of PSc reoccurrence.

While the retrospective analysis in addition to the small size represent limitations, long follow-up period of this study appears unique.

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MESOT 2018 Program now available

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TTS will be exhibiting at MESOT and a large number of TTS members will be attending or presenting at the Congress. There is still time to register, see link below!

CLICK HERE TO SEE THE PROGRAM 


In the News

Transplant with HCV-Infected Kidney Seems Feasible - Small trial found good cure rate, renal function in HCV-negative patients

August 7 - In a cohort of 20 HCV-negative patients, all patients were able to achieve HCV cure after transplantation with an infected kidney, reported Peter Reese, MD, of the University of Pennsylvania in Philadelphia, and colleagues.

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Nonprofit’s plan to take over the U.S. organ network is thwarted

August 3 - A government legal opinion has dashed the hopes of an upstart nonprofit organization that wants to take over operation of the nation’s organ transplant network. Organs for Life, a new nonprofit critical of the way the transplant system is run, hoped to bid for the fiscal 2019 contract to oversee the vast and complex U.S. organ transplant system.

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New system of consent for organ and tissue donation in England announced by ministers

August 5 - The government has announced the introduction of a new “soft” opt-out system for organ and tissue donation in England, in order to tackle a shortage of donors.

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Around 300,000 organ donors registered in Qatar

August 4 - Nearly 35,000 people have registered to become an organ donor since May when Hamad Medical Corporation (HMC) launched its annual organ donation campaign, that was kicked off during Ramadan and will run until the end of this year. Since the Qatar Organ Donor Registry was launched in 2012, around 300,000 donors, or 15 percent of the country’s adult population, have signed up to become an organ dono

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Australians going overseas to get organ transplants in higher numbers than expected

August 2 - To get a more accurate picture, Transplantation Society of Australia and New Zealand (TSANZ) president-elect Toby Coates surveyed members of the transplant community to see how many had dealt with patients who had overseas transplants.

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UCLA researchers discover how the body regenerates blood vessel lining

August 2 - Normal wear and tear damages the blood vessel lining, which is called the endothelial lining. The body, however, has the ability to initiate molecular activity that regenerates and repairs this damage. Now, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have for the first time followed this regeneration in progress and identified the genes and proteins responsible for spurring it.

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TTS 2018 Thank you and Access to recording and photos

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TTS MEMBERS CLICK HERE TO ACCESS THE RECORDINGS

CLICK HERE TO VIEW THE PHOTOS

The Transplantation Society along with the Sociedad Española de Transplant and the Sociedad Madrileña de Trasplantes want to THANK YOU FOR YOUR PARTICIPATION and also acknowledge the exceptional contributions, creativity and support from the many stakeholders and participants that made TTS 2018 the outstanding success that it has become.

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We wish to single out the following groups and convey our deepest thanks to their coordinating leaders:

  • To the many who served on a multitude of sub-committees of the TTS 2018, we wish to express our deepest thanks and appreciation for your commitment over the last two years and the voice of your wisdom on countless decisions made for this Congress.
  • To the numerous award, abstract, plenary, SOTA and Postgraduate Course speakers, session chairs and abstract reviewers from around the world, who contributed their expertise to ensuring that this TTS 2018 had a deep and robust scientific program.
  • To the various sections (CTRMS, TID, IXA and IPTA) and other groups (WTGF, WIT, vGTL, DOI and ITNS) who have created an interesting pre-congress workshop program.
  • To the Young Members Committee and their leaders who organized career networking activities, and delivered a rich cultural and human co-curricular component for the Congress trainees, we wish to convey our most heartfelt appreciation.
  • To the Women in Transplantation Committee for having hosted several learning and networking activities throughout the Congress and thus having promoted the role and furthered the understanding of women in transplantation.
  • To the sponsors and exhibitors without whom it would have been impossible to provide our community with a very rich content in the Exhibit Hall.
  • To the logistics support companies (Rent Multimedia, El Antiguo Convento, Servis, Barcelo Congresos and IFEMA) who provided the staging, audiovisual support, meals at all events and lunches/breaks, signage and booth building, etc; all of which contributed to create a unique ambiance for all aspects of the Congress.
  • The TTS PCO team, for their passion, energy and heart that made this Congress the unique human experience that it became!

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TTS 2018 in Photos

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TTS PRESIDENT AND PRESIDENT-ELECT VISIT TTS IHQ

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On Wednesday, July 25, the staff at TTS IHQ were pleased to welcome Professor Mehmet Haberal and Dr. Marcelo Cantarovich to our International Headquarters. For many of the staff, it was their first time meeting our new President and it offered Professor Haberal the opportunity to inspire our IHQ team about the great work TTS does around the world.

August Issue of Transplantation

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Starting with machine preservation in its many guises, this issue includes a contemporary analysis of the strategies and barriers to transplant tolerance. How many donors could there be, is a question asked and answered. What is the best model of HLA heterogeneity to predict development of DSAs? There is interest for liver, lung, cardiac, intestinal, composite tissue and Islet transplant programs. Much to read and a whole month to read it in.

CLICK HERE TO READ THIS ISSUE (Rquires LOGIN for full articles) 

TTS MEMBERS CLICK HERE for full ACCESS through our referral link 

MESOT 2018 is almost here!

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TTS will be exhibiting at MESOT and a large number of TTS members will be attending or presenting at the Congress. There is still time to register, see link below!

Click here to visit www.mesot2018.com for more information


In the News

Progress in Graft Survival Has Slowed

July 27 - A team led by Maarten Naesens, MD, of University Hospitals Leuven in Belgium, conducted a cohort study of 108,787 recipients of deceased (brain death) donor kidneys across 21 European countries from 1986 to 2015. From 1986 to 1999, 1-, 5- and 10-year hazard rates for allograft loss after transplantation declined by 64%, 53%, and 45%, respectively. From 2000 to 2015, however, these rates declined by 22%, 47%, and 64%, respectively.

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3 biological parents, 1 child, and an international controversy

July 27 - The story of mitochondrial replacement therapy shows how ethically tricky genetic manipulation is becoming.

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How have pediatric VADs advanced and what's next?

July 18 - Pediatric ventricular assist devices (VADs) have been associated with better survival to heart transplantation in recent years but infants and those with congenital heart disease (CHD) continue to have worse outcomes, researchers reported in the Journal of the American College of Cardiology.

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Legal Liver Transplant Focuses Attention On The Human Organ Trade

July 27 - In surely one of the most bizarre stories of recent weeks, former FC Barcelona president, Sandro Rosell, was forced to deny claims that he illegally purchased a human liver for ex-Barcelona defender Eric Abidal in 2012, after a report in Spanish newspaper El Confidencial claimed police had intercepted phone calls of Rosell allegedly admitting the purchase. A statement by FC Barcelona flatly denied the allegations, and pointed out that a Catalan court had shelved an investigation into the matter in 2017.

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