In this podcast, Drs. Macey Levan and Leonardo Riella discuss the Richard Slayman Clinical Workshop on Xenotransplantation, focusing on the historic first human trial of gene-edited pig kidneys at Massachusetts General Hospital. Dr. Riella, Medical Director of Kidney Transplantation, explained how genetic engineering and immunological breakthroughs have overcome barriers to xenotransplantation, including the development of CRISPR-Cas9 tools and new immune suppression drugs. The discussion highlighted the importance of patient selection, ethical considerations, and global collaboration in advancing the field, with Dr. Riella emphasizing that success for patients is measured by scientific learning rather than immediate clinical outcomes. The conversation also addressed public trust and communication challenges, with both speakers agreeing that transparency and sharing of preliminary data are crucial for the field's progress.