TTS Needs Assessment Survey

 

Be Part of TTS’ Future!

We are asking our members to help us understand how TTS can better serve you!
Take the TTS 2021 Needs Assessment Survey.
Results of the survey will directly impact TTS activities!

Participate by: February 22, 2021

Click here to take the survey

ISODP Journal Watch

We are very pleased to announce the launch of the new ISODP Journal Watch as an educational resource and benefit to ISODP members. This curated report of current donation focused literature will serve as a convenient and readily accessible compilation of articles that we hope you will find valuable. We are very grateful to members and colleagues from the NHS Blood and Transplant Services in the United Kingdom for their leadership in conceiving and developing this newsletter.  Special thanks to ISODP Council member Anthony Clarkson and ISODP members Dr. Dale Gardiner and Dr. Alex Manara for their editorial leadership and guidance.

Prof. Faissal A.M. Shaheen
President, ISODP

Upcoming Webinars

Part of BTS and NHSBT Congress Live 2021
THE UK OPT-OUT EXPERIENCE

Thursday, February 25, 2021
14:15 UK TIME (UTC+01:00) / 9:15 AM EST (MONTREAL TIME)

Open to all healthcare professionals

Hosted by Dr Dale Gardiner, the UK National Lead for Organ Donation, a panel of UK donation and transplant leaders, with live links, short video clips, interactive polls and questions, will tell and explore the UK opt-out experience. The session covers legislation, implementation and the onward legacy. Held in collaboration with the International Society for Organ Donation and Procurement, it will be streamed live to a worldwide audience via the NHS Organ Donation Youtube Channel.

NHS Organ Donation YOUTUBE Channel

Asian Society of Transplantation - WIT Webinar
Gender Disparity in Transplant in Asia

Thursday, February 25, 2021
19:00 Seoul / Tokyo time (UTC +09:00)

Open to all healthcare professionals

The Asian Society of Transplantation (AST - myasot.org) in collaboration with the TTS Women in Transplantation (WIT) initiative are hosting webinar on Gender Disparity in Transplant in Asia.

ISN-TTS JOINT WEBINAR
Donor/Recipient Pair:
RISKS VS. GAINS - KIDNEY FUNCTION

FRIDAY, FEBRUARY 26, 2021
3:00 PM CET / 9:00 AM EST (MONTREAL TIME)

Open to all healthcare professionals

Speaker: Marcelo Cantarovich, TTS President
Moderator: Jean Tchervenkov, Montreal, Canada

TRANSPLANT INFECTIOUS DISEASE WEBINAR
COVID-19 VACCINES AND TRANSPLANTATION

Monday, March 1, 2021
7:00 PM CET / 1 PM EST (MONTREAL TIME)

Open to all healthcare professionals

The emergence of the SARS-CoV-2 pandemic has resulted in substantial morbidity and mortality in the US and worldwide. Vaccines have been developed in record time, with several receiving FDA EUA approval. Understanding the role, features, and side effects of these various vaccines is important to help inform use and expectations. Data are lacking in the transplant population, but physicians should be aware of key principles for protecting their patients.

WEEK'S MOST DOWNLOADED PAPER

#TBT to this week's featured top downloaded paper from 2017-18: A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathologyz

New Promo Video!

Check out the new promo video from Transplantation

Call for Applications

Women in Transplantation (WIT) initiative of The Transplantation Society will provide funding to an Early Career Researcher to support research focusing on sex and gender issues relevant to solid organ transplantation.

Letter of intent is due on March 1, 2021

This initiative was made possible with support with One Lambda, a Thermo Fisher Scientific brand, and Sanofi, with each supporting one award.

TTS-ILTS Paired Transplant
Centers Program

Application Deadline Extended to February 24th, 2021


The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging economies.
18 Doctors were awarded the "State Prize' by the President of Mongolia including a kidney and liver transplantation team who successfully introduced kidney and liver transplantation technology to the country on Monday 10 Feb, 2021.
On February 8, President Kh.Battulga issued a decree conferring the state prize to four teams in the health sector. In particular, the president conferred the state prize to members of the liver transplant team of the First State Central Hospital (FSCH) for the introduction of liver transplantation in Mongolia and recognition of their significant contribution to the development of Mongolian medicine since 2011. The team headed by Honored Medical Doctor O.Sergelen includes Director of Cell and Organ Transplantation Coordination Office at the National Center for Health Development P.Batchuluun, Head of Department of Gastroenterology at the Mongolian National University of Medical Sciences (MNUME) D.Davaadorj, Director of Intensive Care at the Anesthesia and Emergency Center of FSCH D.Chuluunbaatar, Head of Anesthesia and Emergency Department at MNUME L.Ganbold, Professor of MNUME S.Erdene, Chief Surgeon of FSCH L.Amgalan, Deputy Head of Treatment Department of the hospital O.Bayarmaa, and medical imaging consultant of Durvun Bileg Hospital B.Erdenebileg. Members of the kidney transplant team of the FSCH received the award for their contribution to the introduction of kidney transplantation in Mongolia. In 1996, the team introduced kidney transplantation, making a significant contribution to the development of Mongolian medicine. They successfully performed kidney transplants on 233 patients to date.

COVID-19 UPDATES

Organ transplant patients can safely receive COVID-19 vaccine, suggests study

Posted on February 9th, 2021 by Rachel Arthur
Johns Hopkins Medicine researchers have studied the reaction of nearly 200 solid organ transplant recipients to their first COVID-19 vaccine shot. The findings, they say, suggest that the Moderna and Pfizer/BioNTech mRNA vaccines can be safely given to this immunocompromised population.

ACTIV Update: Making Major Strides in COVID-19 Therapeutic Development

Posted on February 16th, 2021 by Dr. Francis Collins
Right now, many U.S. hospitals are stretched to the limit trying to help people battling serious cases of COVID-19. But as traumatic as this experience still is for patients and their loved ones, the chances of surviving COVID-19 have in fact significantly improved in the year since the start of the pandemic.

South Africa Study Shows Power of Genomic Surveillance Amid COVID-19 Pandemic

Posted on February 18th, 2021 by Dr. Francis Collins
Photo credit: iStock/Thomas Faull
Public health officials in South Africa have been busy tracing the spread of this genomic variant and others across their country. And a new analysis of such data reveals that dozens of distinct coronavirus variants were already circulating in South Africa well before the appearance of B.1.351.

UPDATE & GUIDANCE ON COVID-19 FOR TRANSPLANT ID CLINICIANS

Posted on January 5, 2021 by TID Section
This is the fifth update of Coronavirus Disease 2019 (COVID-19) Guidance from the TID Section of TTS. It is important to note that information about this disease and our understanding of this virus and its impact on transplantation is evolving rapidly so the guidance may change over time.

«HOT OFF THE PRESS»
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Dr. Millie Samaniego.

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

Agnes Bonifacius et al.
Immunity. 2021 Jan 27;54(2):340-354 doi: 10.1016/j.immuni.2021.01.008.

Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in 82 healthy donors (HDs), 204 recovered (RCs), and 92 active COVID-19 patients (ACs). ACs had high amounts of anti-SARS-CoV-2 nucleocapsid and spike IgG but lymphopenia and overall reduced antiviral T cell responses due to the inflammatory milieu, expression of inhibitory molecules (PD-1, Tim-3) as well as effector caspase-3, -7, and -8 activity in T cells. SARS-CoV-2-specific T cell immunity conferred by polyfunctional, mainly interferon-γ-secreting CD4+ T cells remained stable throughout convalescence, whereas humoral responses declined. Immune responses toward huCoV in RCs with mild disease and strong cellular SARS-CoV-2 T cell reactivity imply a protective role of pre-existing immunity against huCoV.

Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

Stéphane Marot et al.
NATURE COMMUNICATIONS | (2021) 12:844 | https://doi.org/10.1038/s41467-021-21111-9

This study followed 26 health care workers (HCW) with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset of symptoms. All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21 and M2 (p = 0.03) and between D21 and M3 (p < 0.0001). This short-lasting humoral protection supports strong recommendations to maintain infection prevention and control measures in HCW, and suggests that periodic boosts of SARS-CoV-2 vaccination may be required.

Safety of the First Dose of SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients

Boyarsky, Brian et al.
Transplantation 2021 Feb 4. doi: 10.1097/TP.0000000000003654

This Letter to Editor reported 187 solid organ transplant recipients who received their first SARS-CoV-2 vaccination dose between December 16, 2020 and January 16, 2021, of whom 64% identified as front-line healthcare workers. Participants received the Pfizer/BioNTech (50%) or Moderna (50%) mRNA vaccines. There were no self-reported cases of PCR-confirmed SARS-CoV-2 diagnoses between vaccination and study participation, nor were there any reported cases of acute rejection, neurological diagnoses (Guillain-Barré syndrome, Bell's Palsy or neuropathy) or allergic reactions requiring epinephrine. Local site reactions included mild pain (61%), mild redness (7%), and mild swelling (16%). Systemic reactions such as fever and chills were uncommon (4% and 9%), although more-than-baseline fatigue was reported by 38%, headache by 32%, and myalgias by 15%.

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021

Tom T. Shimabukuro et al.
JAMA insights Published Online: February 12, 2021. doi:10.1001/jama.2021.1967

During December 14, 2020 through January 18, 2021, a total of 9 943 247 doses of the Pfizer-BioNTech vaccine and 7 581 429 doses of the Moderna vaccine were reported administered in the US (CDC unpublished data, February 2021). CDC identified 66 case reports received by VAERS that met Brighton Collaboration case definition criteria for anaphylaxis (levels 1, 2 or 3): 47 following PfizerBioNTech vaccine, for a reporting rate of 4.7 cases/million doses administered, and 19 following Moderna vaccine, for a reporting rate of 2.5 cases/million doses administered. When considered in the context of morbidity and mortality from COVID-19, the benefits of vaccination far outweigh the risk of anaphylaxis, which is treatable.

IN THE NEWS

Recent efforts haven't improved access to kidney transplantation

Feb. 11 - New research indicates that efforts to improve access to kidney transplantation in recent years have not been effective. The findings appear in an upcoming issue of JASN.

READ THE FULL ARTICLE

The race to treat a rare, fatal syndrome may help others with common disorders like diabetes

Feb. 11 - For decades, Wolfram syndrome remained enigmatic, untreatable, and fatal. But in the past few years, insights into its mechanism have begun to pay off, leading to the first clinical trials of drugs that might slow the illness and sparking hopes that gene therapy and the CRISPR DNA-editing tool might rectify the underlying genetic flaws.

READ THE FULL ARTICLE

Fecal Microbiota Transplant Effective for Treating Acute GVHD

Feb. 9 - Fecal microbiota transplant (FMT) is a relatively safe and viable treatment option for acute gut graft-versus-host disease (GVHD), according to a study presented at the 2021 TCT Meetings of ASTCT & CIBMTR Digital Experience.

READ THE FULL ARTICLE

Mortality Predictors in Solid Organ Transplant-Associated GVHD

Feb. 7 - Among patients with graft-versus-host disease (GVHD) following solid organ transplantation (SOT), older age and Black race of the organ donor were some of the predictors of increased mortality, according to a study presented the 2021 TCT Meetings of ASTCT & CIBMTR Digital Experience.

READ THE FULL ARTICLE

New Method Developed for "Up-Sizing" Organoids

Feb. 9 - A team of engineers and scientists has developed a method of 'multiplying' organoids: miniature collections of cells that mimic the behaviour of various organs and are promising tools for the study of human biology and disease.

READ THE FULL ARTICLE


UPCOMING MEETINGS AND ANNOUNCEMENTS

The British Transplantation Society (BTS) is an affiliated Society of TTS.
Visit the BTS website for full programme and registration details.

39th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (TSANZASM 2021)

March 14-16, 2021 • Virtual

International Symposium on Benign and Malignant Tumors in Liver With or Without Cirrhosis

June 24-25, 2021 • Kızılcahamam-Turkey

17th Congress of the Intestinal Rehabilitation and Transplant Association (CIRTA 2021)

June 30 - July 2, 2021 • Auckland, New Zealand

The 17th Congress of The Asian Society of Transplantation (CAST 2021)

July 25-28, 2021 • Virtual

17th Congress of the Middle East Society For Organ Transplantation (MESOT 2021)

September 3-5, 2021 • AMMAN-JORDAN
SAVE THE DATE!

ISODP invites you to Las Vegas this November!

Abstract submission is now open, deadline to submit is May 17, 2021.

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