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TTS-WTGF JOINT WEBINAR
COVID Vaccinations for Transplantation

THURSDAY, APRIL 15, 2021
8:00 AM EST (MONTREAL TIME)

Open to all healthcare professionals / Donors / Recipients / Families

Speakers:
Steven Chadban, Paul Harden, Camille Kotton, Michael Ison, Ligia Pierotti

IPTA AHNP - PHTS WEBINAR

April 13, 2021
4:00 PM CET / 11:00 AM EDT (MONTREAL TIME)

Open to all healthcare professionals

IPTA AHNP - PHTS WEBINAR - TUESDAY, APRIL 13, 2021 - 11:00AM EST (MONTREAL TIME)


Highlighted News

COVID-19 fuels demand for lung, heart transplants

April 13 - The U.S. transplant landscape has dramatically changed since surgeons at Chicago-based Northwestern Memorial Hospital performed the nation's first known lung transplant on a COVID-19 patient in June 2020. Now, transplants involving COVID-19 patients are becoming increasingly common nationwide, with nearly two dozen hospitals having performed them, Kaiser Health News reported April 13.

Why the Panic Over Israeli Study on Infections After Vax?

April 20 - Marty Makary and Vinay Prasad on how mild COVID cases after vaccination are freaking people out.

Covid Spawns ‘Completely New Category’ of Organ Transplants

Mark Buchanan of Roopville, Georgia, is wheeled down a hallway by his wife, Melissa, at the University of Florida Health Shands Hospital in January. Buchanan required a double-lung transplant to save his life after contracting covid. CREDIT: Jesse S. Jones / University of Florida Health
April 13 - Nearly 60 transplants were performed through March 31 for patients with covid-related organ disease, according to figures released Monday by the United Network for Organ Sharing, which oversees transplants in the U.S.

Scientists Create Early Embryos That Are Part Human, Part Monkey

Using fluorescent antibody-based stains and advanced microscopy, researchers are able to visualize cells of different species origins in an early stage chimeric embryo. The red color indicates the cells of human origin. CREDIT: Weizhi Ji/Kunming University of Science and Technology
April 15 - For the first time, scientists have created embryos that are a mix of human and monkey cells. The embryos, described in the journal Cell, were created in part to try to find new ways to produce organs for people who need transplants, said the international team of scientists who collaborated in the work. But the research raises a variety of concerns.

Hot off the Press 

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Drs. Enver Akalin, Marlies Reinders and Millie Samaniego.

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

Marie Scully et al.
New Engl J Med, April 16, 2021, DOI: 10.1056/NEJMoa2105385

This article reports findings in 23 patients who presented with thrombosis and thrombocytopenia 6 to 24 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca). In the absence of previous prothrombotic medical conditions, 22 patients presented with acute thrombocytopenia and thrombosis, primarily cerebral venous thrombosis, and 1 patient presented with isolated thrombocytopenia and a hemorrhagic phenotype. All the patients had low or normal fibrinogen levels and elevated d-dimer levels at presentation. No evidence of thrombophilia or causative precipitants was identified. Testing for antibodies to platelet factor 4 (PF4) was positive in 21 patients, negative in 1 patient, and equivocal in 1 patient. The authors recommend that treatment with platelet transfusions be avoided because of the risk of progression in thrombotic symptoms and that the administration of a nonheparin anticoagulant agent and intravenous immune globulin be considered for the first occurrence of these symptoms.

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.
New Engl J Med, April 9, 2021, DOI: 10.1056/NEJMoa2104840
This article presented 11 patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed after vaccination with ChAdOx1 nCov-19. Beginning 5 to 16 days after vaccination, the patients presented with one or more thrombotic events, with the exception of 1 patient, who presented with fatal intracranial hemorrhage. Of the patients with one or more thrombotic events, 9 had cerebral venous thrombosis, 3 had splanchnic-vein thrombosis, 3 had pulmonary embolism, and 4 had other thromboses; of these patients, 6 died. Five patients had disseminated intravascular coagulation. None of the patients had received heparin before symptom onset. All 28 patients who tested positive for antibodies against PF4-heparin tested positive on the platelet-activation assay in the presence of PF4 independent of heparin. Platelet activation was inhibited by high levels of heparin, Fc receptor-blocking monoclonal antibody, and immune globulin (10 mg per milliliter). Additional studies with PF4 or PF4-heparin affinity purified antibodies in 2 patients confirmed PF4-dependent platelet activation.

Spike Antibody Levels of Nursing Home Residents With or Without Prior COVID-19 3Weeks After a Single BNT162b2 Vaccine Dose

Hubert Blain et al.
JAMA, April 15, 2021. doi:10.1001/jama.2021.6042
This article presented 102 nursing home residents, 60 had no prior SARS-CoV-2 infection (COVID-19), 36 had a positive RT-PCR result and were seropositive for SARS-CoV-2 N-protein IgG in June 2020, and 6 had a positive RT-PCR result or were seropositive for SARS-CoV- 2 N-protein IgG. Of the 36 residents who had a positive RT-PCR result and were seropositive for SARS-CoV-2 N-protein IgG in June 2020, 26 remained seropositive in January-February 2021 (72.2%). All 36 residents with prior COVID-19 were seropositive for S-protein IgG after 1 vaccine dose vs 29 of 60 residents (49.2%) without prior COVID-19. This preliminary study suggests that a single dose of BNT162b2 vaccine may be sufficient to obtain a high level of S-protein IgG antibody in nursing home residents previously diagnosed with COVID-19 based on RT-PCR results.

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