It is published by Elsevier quarterly as an online only, Open Access journal and is indexed by the Directory of Open Access Journals. Publication in Intestinal Failure is free of charge until the end of 2025.

Intestinal Failure is a premier peer-reviewed publication, providing a platform for the exchange of current research findings and dialogue of ideas in intestinal transplantation, rehabilitation and failure, as well as parenteral and enteral nutrition management.

Intestinal Failure serves all health professionals involved in the global nutrition and transplant community, including physicians, surgeons, dietitians, nurses, pharmacists, and other allied health professionals, as well as clinical and basic scientists. It bridges the gap between basic and clinical science by publishing comprehensive reviews of translational investigations.

The journal publishes authoritative papers covering basic and clinical science related to intestinal failure, rehabilitation and transplantation. It publishes original research, reviews, clinical guidelines, abstracts of the CIIRTA biennial congress, videos, letters to the editor, and commentaries. The journal is a forum for debate and is a major platform for promoting understanding, improving results, and advancing science in intestinal rehabilitation and transplantation.